Photos, vids, etc ....

Still waiting for those peer reviewed studies .....

If you want to understand why this is not a simple cause/effect relationship that can easily be studied, this explains that there are actually 3 different factors that all have to happen simultaneously, which greatly complicates any possible study attempt.

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Summary: A new study proposes that autism arises when genetic vulnerability, an early environmental trigger, and prolonged activation of the cellular stress response align during critical developmental windows. This “three-hit” metabolic model reframes autism as a disorder of disrupted cellular communication and energy metabolism rather than an inevitable genetic outcome.

By showing that two of the three factors are potentially reversible, the research suggests that early-life screening and metabolic interventions could reduce or prevent a substantial proportion of cases. The model integrates findings across mitochondrial biology, immune signaling, and neural circuit development to offer a unified biological framework for autism.

Key Facts

  • Three Biological Hits: Genetic sensitivity, early environmental stress, and a prolonged cell danger response interact to shape autism risk.
  • Metabolic Signaling Core: Chronic purinergic signaling and disrupted mitochondrial function may alter early neural circuit development.
  • Prevention Potential: Early detection of metabolic stress could reduce or prevent up to half of autism cases.
Source: UCSD

A new University of California San Diego School of Medicine study offers a unified biological model to explain how genetic predispositions and environmental exposures converge to cause autism spectrum disorder (ASD).

The study, published in Mitochondrion on Dec. 9, 2025, describes a “three-hit” metabolic signaling model that reframes autism as a treatable disorder of cellular communication and energy metabolism.

The model also suggests that as many as half of all autism cases might be prevented or reduced with prenatal and early-life interventions.

“Our findings suggest that autism is not the inevitable result of any one gene or exposure, but the outcome of a series of biological interactions, many of which can be modified,” said study author Robert K. Naviaux, M.D., Ph.D., professor of medicine, pediatrics and pathology at UC San Diego School of Medicine.

“By understanding how these genetic and environmental factors stack to alter a child’s developmental trajectory, we can start to imagine preventive care and new approaches to treatment that were previously thought impossible.”
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